今天我们选了openoccess25万篇文献中的一篇有关于潜在老年痴呆的论文，希望对大家有所助益！有兴趣的朋友可以应用specifiko平台的翻译功能进一步了解，有致力于翻译的朋友，不妨试试自己翻译~
文献：
Perispinaletanercept:PotentialasanAlzheimertherapeutic
WSueTGriffin1
JournalofNeuroinflammation:3
DOI:10./--5-3
?Griffin;licenseeBioMedCentralLtd.
点击高亮查看翻译
AbstractTumornecrosisfactor-alpha(TNF)isoneofanumberofsystemicandimmunomodulatingcytokinesthatgenerallyacttopromoteacute-phasereactionsbutcandrivedegenerativechangeswhenchronicallyelevated.TraditionalfocusonTNFhasbeendirectedattheseinflammation-relatedfunctions.OfparticularrelevancetointersectionsbetweenneuroinflammationandneurodegenerationistheabilityofTNFtoincreaseexpressionofinterleukin-1(IL-1),whichinturnincreasesproductionoftheprecursorsnecessaryforformationofamyloidplaques,neurofibrillarytangles,andLewybodies.MorerecentdatahaverevealedthatTNF,oneofthefewgliotransmitters,hasstrikinglyacuteeffectsonsynapticphysiology.These鐧芥穩鐤?鍖椾含鐪嬬櫧鐧滈濂藉尰闄?
